Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158739 | 0.86 | KMT2A (0.75) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL2779476 | 0.80 | PTK2 (0.52) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL29808221 | 0.79 | KMT2A (0.66) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL3510121 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL3147405 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL7980113 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL658145 | 0.78 | MAP4K4 (1.00) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL4755701 | 0.78 | MEN1 (1.00) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL29722919 | 0.78 | MAP4K4 (1.00) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 | |
| SCHEMBL18394452 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAP4K4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085852-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-8-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085857-A1 | 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-06-28 | — | — | WO | disclosed |