Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954170 | 0.92 | MAOB (0.53) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955625 | 0.86 | KDR (0.51) | GRM5MAOBKDRPDGFRBMAPT | |
| SCHEMBL9954102 | 0.86 | MAOB (0.61) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9954695 | 0.85 | PDGFRB (0.66) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955998 | 0.85 | MAOB (0.57) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9953995 | 0.85 | MAOB (0.57) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955054 | 0.83 | MAOB (0.61) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955388 | 0.83 | GRM5 (0.58) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955875 | 0.83 | MAOB (0.61) | GRM5MAOBKDRPDGFRBMAOA | |
| SCHEMBL9955865 | 0.83 | PDGFRB (0.55) | GRM5MAOBKDRPDGFRBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085167-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-06-28 | — | — | WO | disclosed |