SCHEMBL9956313

SCHEMBL9956313

Cc1ccc(-c2ccccc2)c(C(=O)N2CC[C@H]3CN(c4cnc5c(F)c(F)ccc5n4)[C@H]3C2)c1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 20/20 0.63
HCRTR2 O43614 20/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9955930 0.94 HCRTR1 (0.63) HCRTR1HCRTR2
SCHEMBL9954921 0.91 HCRTR1 (0.66) HCRTR1HCRTR2
SCHEMBL9955961 0.90 HCRTR1 (0.69) HCRTR1HCRTR2
SCHEMBL9955064 0.90 HCRTR1 (0.69) HCRTR1HCRTR2
SCHEMBL9955988 0.88 HCRTR1 (0.81) HCRTR1HCRTR2
SCHEMBL9956265 0.87 HCRTR1 (0.66) HCRTR1HCRTR2
SCHEMBL9955362 0.87 HCRTR1 (0.56) HCRTR1HCRTR2
SCHEMBL9955685 0.85 HCRTR1 (0.63) HCRTR1HCRTR2
SCHEMBL9957415 0.85 HCRTR1 (0.45) HCRTR1HCRTR2
SCHEMBL9956119 0.84 HCRTR1 (0.66) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012085857-A1 3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES ACTELION PHARMACEUTICALS LTD (CH) 2012-06-28 WO disclosed