Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | PTPRC | P08575 | 3/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956678 | 0.99 | RXFP1 (0.40) | RXFP1LMNATP53MAPTRORC | |
| SCHEMBL9956711 | 0.93 | HDAC1 (0.38) | RXFP1LMNATP53MAPTRORC | |
| SCHEMBL9955744 | 0.92 | HDAC1 (0.39) | RXFP1LMNATP53MAPTS1PR1 | |
| SCHEMBL9954927 | 0.89 | TP53 (0.43) | RXFP1LMNATP53MAPTRORC | |
| SCHEMBL9955833 | 0.87 | GCGR (0.35) | RXFP1S1PR1CSNK1DCSNK1E | |
| SCHEMBL9956560 | 0.84 | HDAC1 (0.38) | RXFP1LMNATP53MAPTS1PR1 | |
| SCHEMBL9957125 | 0.84 | HDAC1 (0.38) | RXFP1LMNATP53MAPTS1PR1 | |
| SCHEMBL9956649 | 0.84 | PDK2 (0.38) | RXFP1TP53MAPTS1PR1CSNK1D | |
| SCHEMBL9955790 | 0.84 | PDK2 (0.38) | RXFP1TP53MAPTS1PR1CSNK1D | |
| SCHEMBL9956364 | 0.83 | MAPT (0.37) | RXFP1LMNATP53MAPTCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | Hengrui (USA) Ltd. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012088411-A1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | PAMLICO PHARMACEUTICAL INC. (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |