Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 17/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957705 | 0.81 | PIK3C3 (0.56) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957197 | 0.80 | PIK3C3 (0.55) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956986 | 0.80 | PIK3C3 (0.64) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956996 | 0.78 | PIK3C3 (0.61) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957577 | 0.77 | PIK3C3 (0.58) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957073 | 0.77 | PIK3C3 (0.53) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957262 | 0.76 | PIK3C3 (0.52) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956194 | 0.76 | PIK3C3 (0.51) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957402 | 0.75 | PIK3C3 (0.60) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956399 | 0.75 | PIK3C3 (0.60) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655340-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | Novartis AG (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085815-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | NOVARTIS AG (CH) | 2012-06-28 | — | — | WO | disclosed |