Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 18/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.83 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.83 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.83 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PIK3R4 | Q99570 | 1/20 | 0.50 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957746 | 0.91 | PIK3C3 (0.80) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956079 | 0.91 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL15763770 | 0.91 | PIK3C3 (0.83) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957057 | 0.88 | PIK3C3 (0.76) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956225 | 0.87 | PIK3C3 (0.73) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9959843 | 0.83 | PIK3C3 (0.67) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956410 | 0.82 | PIK3C3 (0.70) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9960350 | 0.81 | PIK3C3 (0.65) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957692 | 0.81 | PIK3C3 (0.67) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9956363 | 0.81 | PIK3C3 (0.67) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655340-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | Novartis AG (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085815-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | NOVARTIS AG (CH) | 2012-06-28 | — | — | WO | disclosed |