Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.73 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.73 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248883 | 1.00 | HTR2A (0.73) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| SCHEMBL5171048 | 1.00 | HTR2A (0.73) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| SCHEMBL516439 | 0.93 | TAAR1 (0.59) | HTR2ATAAR1CHRNB2CHRNA4AKT2 | |
| SCHEMBL149259 | 0.85 | HTR2A (1.00) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| SCHEMBL11436330 | 0.84 | TAAR1 (0.63) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| Water SCHEMBL28365853 | 0.83 | HTR2A (0.94) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| Bromide SCHEMBL6737914 | 0.83 | HTR2A (0.94) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| Hydrochloric Acid SCHEMBL8550503 | 0.83 | HTR2A (0.94) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| SCHEMBL29723649 | 0.81 | CNR1 (0.56) | HTR2AHRH1LMNACNR1CNR2 | |
| SCHEMBL3910832 | 0.81 | TAAR1 (0.64) | HTR2ATAAR1CHRNB2CHRNA4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280952-B1 | THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-06-27 | — | — | EP | disclosed |