Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655488 | 0.82 | GCK (0.55) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2656431 | 0.80 | GCK (0.59) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2658334 | 0.80 | GCK (0.56) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2656184 | 0.77 | MEN1 (0.60) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2657487 | 0.77 | GCK (0.67) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2656720 | 0.76 | GCK (0.53) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2658268 | 0.76 | GCK (0.53) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2655612 | 0.76 | GCK (0.59) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2658264 | 0.74 | GCK (0.55) | GCKADORA2ARAB9AMAPTNPC1 | |
| SCHEMBL2660402 | 0.74 | GCK (0.57) | GCKADORA2ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | claimed |