Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953267 | 0.82 | PIK3CD (0.35) | PIK3CDPIK3CBPIK3CAAXLMERTK | |
| SCHEMBL9959539 | 0.80 | PIK3CD (0.33) | PIK3CDPIK3CBPIK3CAAXLMERTK | |
| SCHEMBL9960561 | 0.77 | PIK3CD (0.45) | PIK3CDPIK3CBAXLMERTKPIK3CG | |
| SCHEMBL9929097 | 0.77 | PIK3CD (0.56) | PIK3CDPIK3CBAXLMERTKPIK3CG | |
| SCHEMBL21986424 | 0.77 | PIK3CD (0.41) | PIK3CDPIK3CBAXLMERTKPIK3CG | |
| SCHEMBL9961003 | 0.76 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CAPIK3CGEGFR | |
| SCHEMBL21486193 | 0.75 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CAAXLMERTK | |
| SCHEMBL9928820 | 0.73 | PIK3CD (0.44) | PIK3CDPIK3CBAXLMERTKPIK3CG | |
| SCHEMBL21486180 | 0.73 | PIK3CD (0.44) | PIK3CDPIK3CBAXLMERTKPIK3CG | |
| Trifluoroacetic Acid SCHEMBL21486179 | 0.73 | PIK3CD (0.41) | PIK3CDPIK3CBAXLMERTKPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |