Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527848 | 0.89 | PARP1 (0.65) | PARP1KDM4E | |
| SCHEMBL5534192 | 0.87 | PARP1 (0.62) | PARP1KDM4E | |
| SCHEMBL5534001 | 0.85 | PARP1 (0.58) | PARP1KDM4E | |
| SCHEMBL5523598 | 0.85 | PARP1 (0.60) | PARP1KDM4E | |
| SCHEMBL5528097 | 0.84 | PARP1 (0.67) | PARP1KDM4E | |
| SCHEMBL5525828 | 0.84 | PARP1 (0.64) | PARP1KDM4E | |
| SCHEMBL5525173 | 0.84 | PARP1 (0.59) | PARP1KDM4E | |
| SCHEMBL5526935 | 0.83 | PARP1 (0.58) | PARP1KDM4E | |
| SCHEMBL5523672 | 0.83 | PARP1 (0.58) | PARP1KDM4E | |
| SCHEMBL5534217 | 0.82 | PARP1 (0.64) | PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468748-B1 | Pyrazoloquinolones are potent parp inhibitors | ABBVIE INC (US) | 2016-05-25 | — | — | EP | disclosed |
| EP-1989204-B1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBVIE INC (US) | 2014-05-21 | — | — | EP | disclosed |
| EP-2468748-A1 | Pyrazoloquinolones are potent parp inhibitors | Abbott Laboratories (US) | 2012-06-27 | — | — | EP | disclosed |