Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28945753 | 0.88 | ACE2 (0.59) | ACE2LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL28945792 | 0.88 | ACE2 (0.59) | ACE2LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL28480389 | 0.86 | ACE2 (0.55) | ACE2LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL807542 | 0.84 | ACE2 (0.55) | FAAHCNR1CNR2ACE2LCK | |
| SCHEMBL9142345 | 0.84 | ACE2 (0.55) | FAAHCNR1CNR2ACE2LCK | |
| SCHEMBL14040414 | 0.82 | ACE2 (0.53) | ACE2LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL27950594 | 0.82 | ACE2 (0.58) | FAAHCNR1CNR2ACE2LCK | |
| SCHEMBL11461313 | 0.82 | ACE2 (0.53) | FAAHACE2GPR84FFAR1MAPT | |
| SCHEMBL1420886 | 0.82 | ACE2 (0.52) | FAAHCNR1CNR2ACE2LCK | |
| SCHEMBL28716932 | 0.79 | ACE2 (0.47) | ACE2GPR84CA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013180698-A1 | USE OF FAAH ANTAGONISTS FOR TREATING DRY EYE AND OCULAR PAIN | ALCON RESEARCH, LTD. (US) | 2013-12-05 | — | — | WO | disclosed |
| US-8207226-B1 | Use of FAAH antagonists for treating dry eye and ocular pain | ALCON RESEARCH, LTD. (US) | 2012-06-26 | — | — | US | disclosed |