Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 6/20 | 0.48 |
| ▸ | GCGR | P47871 | 8/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 2/20 | 0.37 |
| ▸ | GIPR | P48546 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951022 | 0.84 | GCGR (0.65) | GCGGCGRGLP1RGIPRMTTP | |
| SCHEMBL9951838 | 0.77 | GCGR (0.45) | GCGGCGRITGB3ITGAVITGB6 | |
| SCHEMBL9960222 | 0.73 | S1PR1 (0.46) | GCGRS1PR1S1PR3GIPR | |
| SCHEMBL9951068 | 0.72 | GCGR (0.68) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9951078 | 0.71 | GCGR (0.73) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9951195 | 0.71 | GCGR (0.73) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9951083 | 0.71 | GCGR (0.73) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9950876 | 0.71 | GCGR (0.72) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9950879 | 0.71 | GCGR (0.72) | GCGGCGRGLP1RGIPR | |
| SCHEMBL9951718 | 0.71 | GCGR (0.72) | GCGGCGRGLP1RGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655331-A1 | GLUCAGON RECEPTOR MODULATORS | Pfizer Inc (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085745-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-06-28 | — | — | WO | disclosed |