Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.47 |
| ▸ | JAK2 | O60674 | 11/20 | 0.46 |
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290091 | 0.96 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCR5 | |
| SCHEMBL2297921 | 0.96 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCR5 | |
| SCHEMBL2285755 | 0.96 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCR5 | |
| SCHEMBL2297227 | 0.96 | JAK1 (0.46) | JAK1JAK2TYK2JAK3CCR5 | |
| SCHEMBL2273150 | 0.87 | JAK1 (0.49) | JAK1JAK2TYK2JAK3CCR5 | |
| SCHEMBL2276523 | 0.86 | JAK1 (0.46) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2276073 | 0.85 | JAK1 (0.44) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2283403 | 0.85 | JAK1 (0.43) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2275891 | 0.84 | JAK2 (0.53) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2275629 | 0.84 | JAK2 (0.52) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |