Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Danirixin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 known ✓ | P25025 | 20/20 | 1.00 |
| ▸ | CX3CR1 | P49238 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Danirixin SCHEMBL29815122 | 1.00 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| Danirixin SCHEMBL12662221 | 1.00 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| Danirixin SCHEMBL1199232 | 1.00 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| Danirixin SCHEMBL29537761 | 1.00 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| Danirixin SCHEMBL1198688 | 1.00 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL1197995 | 0.94 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL12843897 | 0.94 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL1198597 | 0.91 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL12662220 | 0.91 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL1199231 | 0.91 | CXCR2 (1.00) | CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2009992-B1 | IL-8 RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2012-06-27 | — | — | EP | claimed |