Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145478 | 1.00 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL17128609 | 1.00 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL17128608 | 1.00 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL17358931 | 1.00 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL19188702 | 0.93 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL17145476 | 0.91 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL9960206 | 0.91 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL17128478 | 0.91 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL17128480 | 0.91 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL17358932 | 0.91 | NR1H4 (0.78) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655370-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2013-10-30 | — | — | EP | claimed |
| WO-2012087519-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2012-06-28 | — | — | WO | claimed |
| US-9150568-B2 | Compositions and methods for modulating FXR | NOVARTIS AG (CH) | 2015-10-06 | — | — | US | disclosed |
| EP-2655370-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087519-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087519-A1 | COMPOSITIONS AND METHODS FOR MODULATING FXR | IRM LLC (BM) | 2012-06-28 | — | — | WO | disclosed |