Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 18/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950520 | 0.87 | KDR (0.64) | KDRFGFR3 | |
| SCHEMBL9950431 | 0.78 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL9950410 | 0.77 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL9950296 | 0.76 | KDR (0.67) | KDRFGFR3 | |
| SCHEMBL9950524 | 0.75 | KDR (0.71) | KDRFGFR3 | |
| SCHEMBL9949320 | 0.74 | KDR (0.69) | KDRFGFR3 | |
| SCHEMBL9950747 | 0.73 | KDR (0.67) | KDRFGFR3 | |
| SCHEMBL9949743 | 0.73 | FGFR3 (0.71) | KDRFGFR3 | |
| SCHEMBL10177301 | 0.73 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 | |
| SCHEMBL10176578 | 0.73 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088266-A2 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |