Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.68 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 14/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953752 | 1.00 | PIK3CA (0.68) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL9955527 | 0.86 | PIK3CA (0.73) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL9954673 | 0.85 | PIK3CA (0.68) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL9954680 | 0.85 | PIK3CA (0.68) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL26198636 | 0.85 | PIK3CA (0.68) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL931532 | 0.84 | PIK3CA (0.72) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL9955931 | 0.84 | PIK3CA (0.72) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL15346551 | 0.84 | PIK3CA (0.72) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL931536 | 0.84 | PIK3CA (0.75) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG | |
| SCHEMBL931535 | 0.84 | PIK3CA (0.75) | PIK3CAPIK3C3PIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655375-A1 | PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF | SANOFI (FR) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085244-A1 | PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF | SANOFI (FR) | 2012-06-28 | — | — | WO | disclosed |