Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 11/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9949469 | 0.83 | FGFR3 (0.59) | FGFR3FGFR1FYNKDRDYRK3 | |
| SCHEMBL9949699 | 0.77 | FGFR3 (0.57) | FGFR3FGFR1FYNKDR | |
| SCHEMBL10145480 | 0.77 | FYN (0.49) | FGFR3FGFR1FYNKDRDYRK3 | |
| SCHEMBL9949831 | 0.70 | FGFR3 (0.55) | FGFR3FGFR1FYNKDR | |
| SCHEMBL10181279 | 0.70 | FGFR3 (0.55) | FGFR3FGFR1FYNDYRK3DYRK1A | |
| SCHEMBL9949521 | 0.70 | FGFR3 (0.52) | FGFR3FGFR1FYNKDRDYRK3 | |
| SCHEMBL9950098 | 0.69 | FGFR3 (0.70) | FGFR3KDR | |
| SCHEMBL10145502 | 0.68 | FYN (0.53) | FGFR3FGFR1FYNKDRDYRK3 | |
| SCHEMBL10145503 | 0.68 | FGFR3 (0.66) | FGFR3FGFR1FYNDYRK3CCNT1 | |
| SCHEMBL9949662 | 0.67 | FGFR3 (0.61) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088266-A2 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |