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Sugi Predict / Compounds / SCHEMBL9962406

SCHEMBL9962406

SCHEMBL9962406

CC(C)(C)OC(=O)N1CC[C@H](O)[C@@H](N2CCCCC2=O)C1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.44
▸ EPHX1 P07099 1/20 0.40
▸ MAPT P10636 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ GPR119 Q8TDV5 3/20 0.38
▸ TP53 P04637 1/20 0.38
▸ PDE4B Q07343 1/20 0.38
▸ VNN1 O95497 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ RIN1 Q13671 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ PTPN2 P17706 1/20 0.37
▸ PTPN1 P18031 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9962386 0.89 HPGD (0.45) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL28169096 0.89 HPGD (0.45) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL30242026 0.89 HPGD (0.45) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL9933726 0.87 HPGD (0.43) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL16786562 0.86 HPGD (0.42) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL18790624 0.86 HPGD (0.42) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL22240465 0.84 HPGD (0.41) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL2197139 0.82 HPGD (0.43) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL2197135 0.82 HPGD (0.43) HPGDEPHX1MAPTKDM4ETHRB
SCHEMBL2198800 0.82 HPGD (0.43) HPGDEPHX1MAPTKDM4ETHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230046457-A1 BRUTON'S TYROSINE KINASE INHIBITORS BIOGEN MA INC. 2023-02-16 — — US disclosed
US-20200399283-A1 BRUTON'S TYROSINE KINASE INHIBITORS VIRACTA THERAPEUTICS, INC. 2020-12-24 — — US disclosed
US-10577374-B2 Bruton's tyrosine kinase inhibitors SUNESIS PHARMACEUTICALS, INC. (US) 2020-03-03 — — US disclosed
US-10189817-B2 Inhibitors of Bruton's tyrosine kinase BIOGEN MA INC. (US) 2019-01-29 — — US disclosed
US-20180065974-A1 BRUTON'S TYROSINE KINASE INHIBITORS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2018-03-08 — — US disclosed
US-20180065974-A1 BRUTON'S TYROSINE KINASE INHIBITORS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2018-03-08 — — US disclosed
US-9790229-B2 Bruton's tyrosine kinase inhibitors SUNESIS PHARMACEUTICALS, INC. (US) 2017-10-17 — — US disclosed
US-9790229-B2 Bruton's tyrosine kinase inhibitors SUNESIS PHARMACEUTICALS, INC. (US) 2017-10-17 — — US disclosed
US-20170114039-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BIOGEN IDEC MA INC. 2017-04-27 — — US disclosed
US-20170114039-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BIOGEN IDEC MA INC. 2017-04-27 — — US disclosed
US-9249146-B2 Bruton'S tyrosine kinase inhibitors BIOGEN MA INC. (US) 2016-02-02 — — US disclosed
US-9249146-B2 Bruton'S tyrosine kinase inhibitors BIOGEN MA INC. (US) 2016-02-02 — — US disclosed
US-20150126528-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2015-05-07 — — US disclosed
US-20150126528-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2015-05-07 — — US disclosed
US-20140309212-A1 BRUTON'S TYROSINE KINASE INHIBITORS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2014-10-16 — — US disclosed
US-20140309212-A1 BRUTON'S TYROSINE KINASE INHIBITORS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2014-10-16 — — US disclosed
US-8785440-B2 Bruton's tyrosine kinase inhibitors BIOGEN IDEC MA, INC. (US) 2014-07-22 — — US disclosed
US-8785440-B2 Bruton's tyrosine kinase inhibitors BIOGEN IDEC MA, INC. (US) 2014-07-22 — — US disclosed
US-20120157443-A1 BRUTON'S TYROSINE KINASE INHIBITORS SUNESIS PHARMACEUTICALS, INC. (US) 2012-06-21 — — US disclosed
US-20120157443-A1 BRUTON'S TYROSINE KINASE INHIBITORS SUNESIS PHARMACEUTICALS, INC. (US) 2012-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230046457-A1 BRUTON'S TYROSINE KINASE INHIBITORS BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885
US-20150126528-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, LYN HPGD 4585/4885EPHX1 2985/4885MAPT 4175/4885
US-20170114039-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, LYN HPGD 4585/4885EPHX1 2985/4885MAPT 4175/4885
US-20140309212-A1 BRUTON'S TYROSINE KINASE INHIBITORS BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885
US-10189817-B2 Inhibitors of Bruton's tyrosine kinase ABL1, BTK, LYN HPGD 4585/4885EPHX1 2985/4885MAPT 4175/4885
US-20200399283-A1 BRUTON'S TYROSINE KINASE INHIBITORS BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885
US-20120157443-A1 BRUTON'S TYROSINE KINASE INHIBITORS BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885
US-10577374-B2 Bruton's tyrosine kinase inhibitors BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885
US-20180065974-A1 BRUTON'S TYROSINE KINASE INHIBITORS BTK, ABL1, SYK HPGD 4535/4885EPHX1 2553/4885MAPT 4120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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