Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.56 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.56 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13651238 | 0.86 | CA9 (0.76) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| Etebenecid SCHEMBL1643610 | 0.85 | SMN1; SMN2 (0.75) | HTTSMN1; SMN2ALDH1A1NPSR1LMNA | |
| SCHEMBL4638414 | 0.84 | HTT (0.61) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL2492611 | 0.84 | HTT (0.61) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL13545215 | 0.84 | HTT (0.61) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL11534484 | 0.82 | SMN1; SMN2 (0.62) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL4345155 | 0.81 | HTT (0.58) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL13543237 | 0.81 | HTT (0.66) | HTTSMN1; SMN2ALDH1A1NPSR1PKM | |
| SCHEMBL10154240 | 0.81 | CA12 (0.77) | HTTSMN1; SMN2ALDH1A1NPSR1LMNA | |
| SCHEMBL7021479 | 0.80 | SMN1; SMN2 (0.64) | HTTSMN1; SMN2ALDH1A1NPSR1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501242-B2 | Methods and compositions for treating neoplasia | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120156212-A1 | METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION | 2012-06-21 | — | — | US | disclosed |
| US-4137408-A | BACTERICIDES, ANTIBIOTICS | WARNER-LAMBERT (US) | 1979-01-30 | — | — | US | disclosed |
| US-4101661-A | PENICILLINS, CEPHALOSPORINS | WARNER-LAMBERT (US) | 1978-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120156212-A1 | METHODS AND COMPOSITIONS FOR TREATING NEOPLASIA | TYMS, UNG, TYMP | HTT 2479/4885SMN1; SMN2 3011/4885ALDH1A1 941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.