Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IL2 | P60568 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761833 | 0.91 | KMT2A (0.50) | STIM1ORAI1KMT2AIL2MAPT | |
| SCHEMBL12093655 | 0.83 | STIM1 (0.61) | STIM1ORAI1KMT2AIL2TRPC1 | |
| SCHEMBL4769856 | 0.82 | IL2 (0.62) | STIM1ORAI1KMT2AIL2MAPT | |
| SCHEMBL3809188 | 0.81 | STIM1 (0.62) | STIM1ORAI1KMT2AIL2MAPT | |
| SCHEMBL4762627 | 0.80 | STIM1 (0.53) | STIM1ORAI1IL2MAPTTRPC1 | |
| SCHEMBL4762957 | 0.80 | STIM1 (0.53) | STIM1ORAI1IL2TRPC1TRPC3 | |
| SCHEMBL4762642 | 0.80 | STIM1 (0.45) | STIM1ORAI1IL2NPC1RAB9A | |
| SCHEMBL4764885 | 0.80 | STIM1 (0.52) | STIM1ORAI1IL2MAPTTRPC1 | |
| SCHEMBL4762889 | 0.80 | STIM1 (0.52) | STIM1ORAI1IL2TRPC1TRPC3 | |
| SCHEMBL4769520 | 0.80 | STIM1 (0.52) | STIM1ORAI1IL2MAPTTRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202999-B2 | biphenyl and pyridylphenyl derivatives such as 2,6-Difluoro-N-[2'-methyl-5'-(pyridine-3-yl)-biphenyl-4-yl]-benzamide, used as immunosuppressants for the treatmet or prevent allergies, inflammatory and immune disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2012-06-19 | — | — | US | disclosed |
| US-8202999-B2 | biphenyl and pyridylphenyl derivatives such as 2,6-Difluoro-N-[2'-methyl-5'-(pyridine-3-yl)-biphenyl-4-yl]-benzamide, used as immunosuppressants for the treatmet or prevent allergies, inflammatory and immune disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2012-06-19 | — | — | US | disclosed |