Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30352893 | 0.84 | EPHX2 (0.55) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL25009521 | 0.83 | MAPT (0.49) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL16407626 | 0.82 | MAPT (0.55) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL642920 | 0.82 | NSD2 (0.49) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL30271400 | 0.82 | NSD2 (0.49) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL30271381 | 0.82 | MAPT (0.48) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL25010846 | 0.82 | MAPT (0.48) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL9965438 | 0.80 | NSD2 (0.50) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL25011533 | 0.80 | NSD2 (0.50) | NSD2MAPTJAK1BRD4JAK2 | |
| SCHEMBL9965473 | 0.80 | TSHR (0.54) | NSD2MAPTJAK1BRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-B1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | STERIX LTD (GB) | 2012-06-20 | — | — | EP | disclosed |
| WO-2007003934-A2 | 17BETA-HYDR0XYSTER0ID DEHYDROGENASE TYPE 3 (17BETA-HSD3 ) INHIBITORS | STERIX LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |