Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191759 | 0.83 | KDM4E (0.51) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL6445301 | 0.82 | SMN1; SMN2 (0.53) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL3932945 | 0.80 | KDM4E (0.56) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL31059181 | 0.80 | KDM4E (0.68) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL12819456 | 0.80 | KDM4E (0.68) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL31059180 | 0.80 | KDM4E (0.68) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL30086100 | 0.80 | KDM4E (0.58) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL229256 | 0.80 | KDM4E (0.58) | KDM4ETSHRPOLBTDP1NPSR1 | |
| Hydrochloric Acid SCHEMBL29367467 | 0.78 | KDM4E (0.57) | KDM4ETSHRPOLBTDP1NPSR1 | |
| SCHEMBL6227384 | 0.77 | CYP1A2 (0.49) | KDM4ETSHRPOLBTDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576586-B1 | C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2362909-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2011008230-A2 | RAPAMYCIN DERIVATIVES AND ETHERS OF N-PROPANOLAMINES AND USES RELATED TO INFECTION | Zirus, Inc. (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010039778-A2 | MAMMALIAN GENES INVOLVED IN INFECTION | Zirus, Inc. (US) | 2010-04-08 | — | — | WO | disclosed |
| US-7160877-B2 | Aliphatic nitrogen-containing 5-membered ring compound | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-0734389-B1 | RAPAMYCIN DERIVATIVES USEFUL AS IMMUNOSUPPRESSANTS | NOVARTIS AG (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5985890-A | Rapamycin derivatives | NOVARTIS AG (CH) | 1999-11-16 | — | — | US | disclosed |
| US-5912253-A | 16-DEMETHOXY DERIVATIVES HAVING GREATER STABILITY AND BIOAVAILABILITY; FOR USE AS IMMUNOSUPPRESSANTS | NOVARTIS AG (CH) | 1999-06-15 | — | — | US | disclosed |
| EP-0833828-A1 | RAPAMYCIN DERIVATIVES | Novartis AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996041807-A1 | RAPAMYCIN DERIVATIVES | NOVARTIS AG (CH) | 1996-12-27 | — | — | WO | disclosed |
| EP-0734389-A1 | RAPAMYCIN DERIVATIVES USEFUL AS IMMUNOSUPPRESSANTS | Novartis AG (CH) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016691-A1 | RAPAMYCIN DERIVATIVES USEFUL AS IMMUNOSUPPRESSANTS | SANDOZ LTD. (CH) | 1995-06-22 | — | — | WO | disclosed |
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |