Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.49 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332611 | 0.90 | CHEK2 (0.54) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2332607 | 0.90 | CHEK2 (0.54) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2328109 | 0.89 | CHEK2 (0.49) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2328113 | 0.89 | CHEK2 (0.49) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2335247 | 0.85 | CHEK2 (0.54) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2335252 | 0.85 | CHEK2 (0.54) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL2332326 | 0.83 | CHEK2 (0.62) | CHEK2CHEK1BTKSMARCA2SMARCA4 | |
| SCHEMBL2332321 | 0.83 | CHEK2 (0.62) | CHEK2CHEK1BTKSMARCA2SMARCA4 | |
| SCHEMBL9966984 | 0.82 | CHEK2 (0.54) | CHEK2CHEK1DNMT3APIK3CDBTK | |
| SCHEMBL9966927 | 0.81 | CHEK2 (0.57) | CHEK2CHEK1DNMT3APIK3CDBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227460-B1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2012-06-20 | — | — | EP | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |