Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.65 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882901 | 0.89 | GAA (0.57) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL3637457 | 0.84 | GFER (0.53) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL9968014 | 0.82 | HPGD (0.74) | HSP90AA1HSP90AB1GAAHPGDUSP2 | |
| SCHEMBL3642307 | 0.80 | TSHR (0.56) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL21545963 | 0.79 | GAA (0.50) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL29560043 | 0.79 | GAA (0.50) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL3687132 | 0.75 | TSHR (0.49) | HSP90AA1HSP90AB1HPGDIDH1USP2 | |
| SCHEMBL10079157 | 0.75 | GFER (0.78) | HSP90AA1HSP90AB1HPGDUSP2TSHR | |
| SCHEMBL3646369 | 0.74 | TSHR (0.52) | HSP90AA1HSP90AB1GAAHPGDIDH1 | |
| SCHEMBL22095989 | 0.74 | MAPK1 (0.71) | HSP90AA1HSP90AB1GAAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088187-A1 | ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012082862-A2 | ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088187-A1 | ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, NR5A1, ESRRB | HSP90AA1 1154/4885HSP90AB1 807/4885GAA 2513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.