Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 20/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968765 | 0.85 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9930664 | 0.84 | MCHR1 (0.98) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL9931567 | 0.83 | MCHR1 (0.73) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL9968705 | 0.82 | MCHR1 (0.56) | MCHR1 | |
| SCHEMBL9968707 | 0.82 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9930465 | 0.82 | MCHR1 (0.98) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL9968761 | 0.78 | MCHR1 (0.69) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL4537335 | 0.76 | MCHR1 (0.66) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL4532069 | 0.75 | MCHR1 (0.58) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL539304 | 0.74 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993765-B2 | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120157460-A1 | TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157460-A1 | TETRAHYDRO-AZACARBOLINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USES THEREOF | MCHR1, MCHR2, MC5R | MCHR1 1/4885KCNH2 1973/4885CYP3A4 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.