Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 15/20 | 0.61 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | AMD1 | P17707 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940700 | 1.00 | DOT1L (0.61) | DOT1LDNMT1AMD1 | |
| SCHEMBL9940701 | 1.00 | DOT1L (0.61) | DOT1LDNMT1AMD1 | |
| SCHEMBL15395669 | 0.91 | DOT1L (0.51) | DOT1LDNMT1 | |
| SCHEMBL19111255 | 0.90 | DOT1L (0.66) | DOT1LDNMT1 | |
| SCHEMBL9940528 | 0.90 | DOT1L (0.66) | DOT1LDNMT1 | |
| SCHEMBL14873790 | 0.90 | DOT1L (0.66) | DOT1LDNMT1 | |
| SCHEMBL9940505 | 0.89 | DOT1L (0.49) | DOT1LDNMT1AMD1 | |
| SCHEMBL9970201 | 0.87 | DOT1L (0.58) | DOT1L | |
| SCHEMBL9940637 | 0.87 | DOT1L (0.58) | DOT1L | |
| SCHEMBL9940737 | 0.86 | DOT1L (0.59) | DOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |