Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 14/20 | 0.62 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | AMD1 | P17707 | 2/20 | 0.48 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940734 | 1.00 | DOT1L (0.62) | DOT1LDNMT1METTL3AMD1TRDMT1 | |
| SCHEMBL9940834 | 0.91 | DOT1L (0.61) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9940665 | 0.90 | DOT1L (0.60) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9970700 | 0.90 | DOT1L (0.60) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9940474 | 0.88 | DOT1L (0.56) | DOT1LDNMT1METTL3AMD1TRDMT1 | |
| SCHEMBL9970231 | 0.88 | DOT1L (0.58) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9940679 | 0.88 | DOT1L (0.58) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9940699 | 0.87 | DOT1L (0.64) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL15395705 | 0.86 | DOT1L (0.60) | DOT1LDNMT1AMD1TRDMT1 | |
| SCHEMBL9940745 | 0.86 | DOT1L (0.57) | DOT1LDNMT1AMD1TRDMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013055397-A1 | INHIBITION AND ENHANCEMENT OF REPROGRAMMING BY CHROMATIN MODIFYING ENZYMES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |