Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 15/20 | 0.76 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.64 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.57 |
| ▸ | AMD1 | P17707 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942302 | 1.00 | DOT1L (0.76) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL9942303 | 1.00 | DOT1L (0.76) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL9940747 | 0.94 | DOT1L (0.78) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL9940749 | 0.94 | DOT1L (0.78) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL9970246 | 0.92 | DOT1L (0.75) | DOT1LDNMT1EZH2 | |
| SCHEMBL9936470 | 0.92 | DOT1L (0.75) | DOT1LDNMT1EZH2 | |
| SCHEMBL9936467 | 0.92 | DOT1L (0.75) | DOT1LDNMT1EZH2 | |
| SCHEMBL9937269 | 0.91 | DOT1L (0.84) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL17568800 | 0.91 | DOT1L (0.84) | DOT1LDNMT1EZH2AMD1 | |
| SCHEMBL9937271 | 0.91 | DOT1L (0.84) | DOT1LDNMT1EZH2AMD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |