Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 17/20 | 0.67 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.61 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705100 | 1.00 | DOT1L (0.67) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL9940827 | 0.96 | DOT1L (0.67) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL9970730 | 0.96 | DOT1L (0.67) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15829365 | 0.93 | DOT1L (0.64) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15598780 | 0.93 | DOT1L (0.64) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL18659716 | 0.93 | DOT1L (0.63) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL16129574 | 0.92 | DOT1L (0.78) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15598648 | 0.92 | DOT1L (0.78) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15389762 | 0.92 | DOT1L (0.64) | DOT1LDNMT1PI4KAPI4K2BPI4K2A | |
| SCHEMBL15395708 | 0.92 | DOT1L (0.66) | DOT1LDNMT1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |