Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.65 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.65 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.65 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | AMD1 | P17707 | 2/20 | 0.52 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 8/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.48 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15389324 | 1.00 | PI4KA (0.65) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970584 | 0.97 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970248 | 0.97 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940651 | 0.97 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970623 | 0.95 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17773141 | 0.93 | PI4KA (0.65) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395746 | 0.92 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395697 | 0.88 | PI4KA (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9936622 | 0.88 | PI4KA (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970658 | 0.88 | PI4KA (0.61) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |