Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18628987 | 0.86 | NR1H2 (0.49) | ALDH1A1FKBP1ANR1H2NR1H3EPHX1 | |
| SCHEMBL10303644 | 0.86 | NR1H2 (0.49) | ALDH1A1FKBP1ANR1H2NR1H3EPHX1 | |
| SCHEMBL27947480 | 0.86 | NR1H2 (0.49) | ALDH1A1FKBP1ANR1H2NR1H3EPHX1 | |
| SCHEMBL2126895 | 0.81 | HPGD (0.46) | LMNAALDH1A1TSHRL3MBTL1EPHX1 | |
| SCHEMBL27216297 | 0.72 | CYP3A4 (0.37) | LMNAALDH1A1TSHRTDP1CYP3A4 | |
| SCHEMBL16409183 | 0.72 | CYP3A4 (0.39) | LMNAALDH1A1TSHRTDP1CYP3A4 | |
| SCHEMBL10008547 | 0.72 | HPGD (0.44) | LMNAALDH1A1TSHRL3MBTL1EPHX1 | |
| SCHEMBL20505385 | 0.71 | KDM4E (0.50) | LMNAALDH1A1TSHRTDP1L3MBTL1 | |
| SCHEMBL11229001 | 0.70 | CYP3A4 (0.37) | LMNAALDH1A1TSHRTDP1CYP3A4 | |
| SCHEMBL23535262 | 0.69 | MEN1 (0.43) | LMNAKDM4ENPC1RAB9ACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871774-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-28 | — | — | US | disclosed |
| WO-2012083121-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |