Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929174 | 0.88 | PIK3CD (0.49) | PIK3CDAXLMERTKPIK3CGPIK3R2 | |
| Trifluoroacetic Acid SCHEMBL9928934 | 0.83 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3R2 | |
| SCHEMBL9928933 | 0.80 | PIK3CD (0.43) | PIK3CDAXLMERTKPIK3CGPIK3CB | |
| Trifluoroacetic Acid SCHEMBL9929043 | 0.77 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R2PIK3CB | |
| SCHEMBL9929401 | 0.76 | PIK3CD (0.57) | PIK3CDAXLMERTKPIK3CGPIK3R2 | |
| SCHEMBL9967868 | 0.75 | PIK3CD (0.48) | PIK3CD | |
| SCHEMBL9929003 | 0.74 | PIK3CD (0.55) | PIK3CDAXLMERTKPIK3CGPIK3R2 | |
| Trifluoroacetic Acid SCHEMBL9928750 | 0.71 | PIK3CD (0.50) | PIK3CDAXLMERTKPIK3CGPIK3R2 | |
| SCHEMBL10278702 | 0.70 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3R2 | |
| SCHEMBL9929022 | 0.69 | PIK3CD (0.59) | PIK3CDAXLMERTKPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157430-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157430-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | PIK3CA, PIK3CD, PI4KB | PIK3CD 2/4885AXL 1575/4885MERTK 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.