⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15482160 | 0.69 | — | — | |
| SCHEMBL19681312 | 0.69 | — | — | |
| SCHEMBL9971072 | 0.69 | — | — | |
| SCHEMBL23341356 | 0.61 | — | — | |
| SCHEMBL9956770 | 0.60 | — | — | |
| SCHEMBL9956771 | 0.60 | — | — | |
| SCHEMBL19681311 | 0.59 | — | — | |
| Hydrochloric Acid SCHEMBL11361093 | 0.57 | — | — | |
| SCHEMBL10850070 | 0.55 | — | — | |
| SCHEMBL10850073 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570088-B2 | Blood brain barrier-penetrating oximes for cholinesterase reactivation | HUMAN BIOMOLECULAR RES FOUNDATION (US) | 2020-02-25 | — | — | US | disclosed |
| US-20170349538-A1 | Blood Brain Barrier-Penetrating Oximes for Cholinesterase Reactivation | Human BioMolecular Research Foundation (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170349538-A1 | Blood Brain Barrier-Penetrating Oximes for Cholinesterase Reactivation | Human BioMolecular Research Foundation (US) | 2017-12-07 | — | — | US | disclosed |
| US-9751831-B2 | Blood brain barrier-penetrating oximes for cholistenerases reactivation | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751831-B2 | Blood brain barrier-penetrating oximes for cholistenerases reactivation | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2017-09-05 | — | — | US | disclosed |
| US-20140051712-A1 | BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE | 2014-02-20 | — | — | US | disclosed |
| US-20140051712-A1 | BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE | 2014-02-20 | — | — | US | disclosed |
| WO-2012083261-A1 | BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-06-21 | — | — | WO | disclosed |