Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 17/20 | 0.61 |
| ▸ | EGFR | P00533 | 16/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 3/20 | 0.53 |
| ▸ | INSR | P06213 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | PLK1 | P53350 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478977 | 0.93 | EGFR (0.60) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL6955065 | 0.93 | EGFR (0.60) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL2478975 | 0.93 | EGFR (0.60) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL29651885 | 0.93 | EGFR (0.60) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL29651886 | 0.93 | EGFR (0.62) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL3698690 | 0.93 | EGFR (0.62) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL6959360 | 0.93 | EGFR (0.62) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL3698693 | 0.93 | EGFR (0.62) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL12202155 | 0.92 | EGFR (0.61) | ERBB2EGFRGAKERBB4ABL1 | |
| SCHEMBL20436802 | 0.92 | EGFR (0.65) | ERBB2EGFRGAKERBB4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |