SCHEMBL9974227

SCHEMBL9974227

C=C(NCCc1c[nH]c2ccc(C(F)(F)F)cc12)c1ccc(Cc2cccc(F)c2)cc1

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SNCA P37840 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9942405 0.90 SNCA (1.00) SNCA
SCHEMBL15313042 0.79 SNCA (1.00) SNCA
SCHEMBL15313102 0.79 SNCA (1.00) SNCA
SCHEMBL9937946 0.79 SNCA (0.82) SNCA
SCHEMBL15313132 0.78 SNCA (0.81) SNCA
SCHEMBL9938370 0.78 SNCA (0.81) SNCA
SCHEMBL9938890 0.78 SNCA (0.81) SNCA
SCHEMBL9938513 0.78 SNCA (1.00) SNCA
SCHEMBL28118081 0.77 SNCA (0.69) SNCA
SCHEMBL9938802 0.76 SNCA (1.00) SNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012080221-A1 NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2012-06-21 WO disclosed