SCHEMBL9974983

SCHEMBL9974983

c1cncc(-c2ccc(-c3cc(-c4ccc(-c5cccnc5)cc4)c(-c4ccc(-c5ccncc5)cc4)cc3-c3ccc(-c4ccncc4)cc3)cc2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.60
CYP3A4 P08684 2/20 0.60
ALDH1A1 P00352 1/20 0.60
CYP1A2 P05177 1/20 0.60
PIK3CA P42336 1/20 0.59
MKNK1 Q9BUB5 5/20 0.56
MKNK2 Q9HBH9 5/20 0.56
CYP11B2 P19099 2/20 0.52
DYRK1A Q13627 2/20 0.52
DYRK1B Q9Y463 2/20 0.52
KIF11 P52732 1/20 0.52
CYP17A1 P05093 1/20 0.52
CYP19A1 P11511 1/20 0.52
CYP11B1 P15538 1/20 0.52
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
CYP2C9 P11712 1/20 0.48
CYP2B6 P20813 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9974942 1.00 CYP2A6 (0.60) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA
SCHEMBL9974944 0.96 MKNK1 (0.56) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA
SCHEMBL14655793 0.94 CYP2A6 (0.68) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL9974941 0.92 MKNK1 (0.66) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL9974947 0.90 CYP2A6 (0.62) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA
SCHEMBL9974924 0.90 CYP2A6 (0.62) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA
SCHEMBL320526 0.87 CYP2A6 (0.79) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL29626674 0.87 CYP2A6 (0.79) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL9974958 0.86 CYP2A6 (0.73) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA
SCHEMBL12068188 0.85 CYP2A6 (0.68) CYP2A6CYP3A4ALDH1A1CYP1A2PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012081541-A1 1, 2, 4, 5-SUBSTITUTED PHENYL DERIVATIVE, PRODUCTION METHOD FOR SAME, AND ORGANIC ELECTROLUMINESCENT ELEMENT 東ソー株式会社 (JP) 2012-06-21 WO disclosed