⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8415297 | 0.96 | ODC1 (0.93) | — | |
| Hydrochloric Acid SCHEMBL2728929 | 0.96 | — | — | |
| Hydrochloric Acid SCHEMBL3456337 | 0.96 | — | — | |
| SCHEMBL170607 | 0.89 | — | — | |
| SCHEMBL4068272 | 0.86 | — | — | |
| SCHEMBL22895260 | 0.86 | ODC1 (0.75) | — | |
| SCHEMBL10800049 | 0.86 | ODC1 (0.75) | — | |
| Hydrochloric Acid SCHEMBL8416234 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL8416229 | 0.86 | ODC1 (0.75) | — | |
| SCHEMBL7543585 | 0.86 | ODC1 (0.75) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 235 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023249908-A1 | USE OF NON-TOXIC POLYAMINE ANALOGUES AND/OR INHIBITORS OF POLYAMINE BIOSYNTHESIS TO RE-BALANCE NATURAL POLYAMINE LEVELS IN SNYDER-ROBINSON SYNDROME AND RELATED DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2023-12-28 | — | — | WO | claimed |
| US-20210139610-A1 | COMPOSITIONS AND METHODS FOR MEDIATING EPS | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2021-05-13 | — | — | US | claimed |
| EP-3813811-A2 | COMPOSITIONS AND METHODS FOR MEDIATING EPS | Research Institute at Nationwide Children's Hospital (US) | 2021-05-05 | — | — | EP | claimed |
| CN-112672736-A | Compositions and methods for mediating EPS | 国家儿童医院研究所 | 2021-04-16 | — | — | CN | claimed |
| US-20200390896-A1 | Polyamine Prodrugs And Polyamine Prodrug Formulations | UNIV NEBRASKA (US) | 2020-12-17 | — | — | US | claimed |
| WO-2019173446-A1 | POLYAMINE PRODRUGS AND POLYAMINE PRODRUG FORMULATIONS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2019-09-12 | — | — | WO | claimed |
| US-8609644-B2 | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2013-12-17 | — | — | US | claimed |
| EP-2004668-B1 | AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA TAU IND FARMACEUTI (IT) | 2013-03-13 | — | — | EP | claimed |
| US-20110053902-A1 | AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2011-03-03 | — | — | US | claimed |
| CN-101466725-A | Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders | SIGMA TAU IND FARMACEUTI (IT) | 2009-06-24 | — | — | CN | claimed |
| EP-2004668-A2 | AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-12-24 | — | — | EP | claimed |
| WO-2007118832-A2 | AMINO DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-10-25 | — | — | WO | claimed |
| US-20040229886-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK BIOTECH, INC. & SHIONOGI CO., LTD. | 2004-11-18 | — | — | US | claimed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | claimed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| US-20030203956-A1 | Method of using a cyclooxygenase-2 inhibitor and one or more ornithine decarboxylase inhibitors as a combination therapy in the treatment of neoplasia | PHARMACIA CORPORATION | 2003-10-30 | — | — | US | claimed |
| US-6482866-B1 | Viscoelastic surfactant fluids and related methods of use | SCHLUMBERGER TECHNOLOGY CORPORATION | 2002-11-19 | — | — | US | claimed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | claimed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | claimed |
| US-5466439-A | Polymeric contrast enhancing agents for magnetic resonance images | MAGNETIC RESEARCH, INC. (US) | 1995-11-14 | — | — | US | claimed |