SCHEMBL9975321

SCHEMBL9975321

c1cncc(-c2cc(-c3cccnc3)nc(-c3ccc(-c4nc(-c5cccnc5)cc(-c5cccnc5)n4)cc3)n2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.63
CYP2A6 P11509 5/20 0.56
ALDH1A1 P00352 4/20 0.56
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56
MAPT P10636 2/20 0.54
HPGD P15428 2/20 0.54
KDM4E B2RXH2 1/20 0.54
LMNA P02545 1/20 0.54
TP53 P04637 1/20 0.54
ALOX15 P16050 1/20 0.54
HTT P42858 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HSD17B10 Q99714 1/20 0.54
CYP11B1 P15538 2/20 0.53
CYP11B2 P19099 2/20 0.53
METAP2 P50579 1/20 0.53
SIRT3 Q9NTG7 1/20 0.53
CYP17A1 P05093 1/20 0.53
MKNK1 Q9BUB5 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9920497 0.94 CYP19A1 (0.68) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL21623613 0.93 CYP19A1 (0.71) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL24590289 0.93 CYP19A1 (0.71) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL21709035 0.92 CYP19A1 (0.59) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL24941653 0.91 CYP19A1 (0.59) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL24589928 0.91 CYP19A1 (0.59) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL18270327 0.89 CYP19A1 (0.72) CYP19A1CYP2A6ALDH1A1MAPTHPGD
SCHEMBL24527291 0.89 CYP19A1 (0.66) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL24590034 0.89 CYP19A1 (0.61) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4
SCHEMBL17945297 0.89 CYP19A1 (0.66) CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012080052-A1 BISPYRIMIDINES FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2012-06-21 WO disclosed