Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.55 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.55 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.55 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 11/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28907176 | 0.85 | C5AR1 (0.61) | C5AR1MEN1MAPTKMT2A | |
| SCHEMBL13996563 | 0.85 | ACP1 (0.53) | ACP1PTPN12PTPN13SSU72NPC1 | |
| SCHEMBL6978325 | 0.85 | ERBB2 (0.48) | ACP1PTPN12PTPN13SSU72EGFR | |
| SCHEMBL22793766 | 0.85 | PPARA (0.51) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL15304787 | 0.84 | ACP1 (0.55) | ACP1PTPN12PTPN13SSU72NPC1 | |
| SCHEMBL9975357 | 0.84 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL6962757 | 0.84 | ACP1 (0.55) | ACP1PTPN12PTPN13SSU72NPC1 | |
| SCHEMBL13994027 | 0.84 | ACP1 (0.52) | ACP1PTPN12PTPN13SSU72NPC1 | |
| SCHEMBL6978367 | 0.83 | KDR (0.52) | EGFRERBB2GRM4PTK6MEN1 | |
| SCHEMBL6979978 | 0.83 | FFAR4 (0.54) | SMN1; SMN2MRGPRX4C5AR1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | ERBB2, EGFR, ABL1 | ACP1 635/4885PTPN12 47/4885PTPN13 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.