Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9975954 | 0.87 | AKT1 (1.00) | AKT1 | |
| SCHEMBL15395261 | 0.87 | AKT1 (1.00) | AKT1 | |
| Hydrochloric Acid SCHEMBL15388292 | 0.86 | AKT1 (0.98) | AKT1 | |
| SCHEMBL9976142 | 0.86 | AKT1 (1.00) | AKT1 | |
| SCHEMBL9976204 | 0.85 | AKT1 (0.81) | AKT1 | |
| SCHEMBL15388167 | 0.84 | AKT1 (1.00) | AKT1 | |
| SCHEMBL16892850 | 0.83 | AKT1 (0.82) | AKT1 | |
| SCHEMBL9975922 | 0.83 | AKT1 (1.00) | AKT1 | |
| SCHEMBL9975955 | 0.80 | AKT1 (1.00) | AKT1 | |
| SCHEMBL9976199 | 0.80 | AKT1 (1.00) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651949-B1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER IP GMBH (DE) | 2015-07-15 | — | — | EP | claimed |
| US-8987286-B2 | Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | claimed |
| US-20130310405-A1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-21 | — | — | US | claimed |
| EP-2651949-B1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER IP GMBH (DE) | 2015-07-15 | — | — | EP | disclosed |
| EP-2651949-B1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER IP GMBH (DE) | 2015-07-15 | — | — | EP | disclosed |
| US-8987286-B2 | Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-8987286-B2 | Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-8987286-B2 | Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-03-24 | — | — | US | disclosed |
| US-20130310405-A1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| US-20130310405-A1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
| WO-2012080237-A1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310405-A1 | SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY | PIK3CA, PIK3CD, PIK3CB | AKT1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.