Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 18/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 18/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 18/20 | 1.00 |
| ▸ | TNF | P01375 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193446 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637197 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL1193568 | 0.88 | PDE4B (0.77) | PDE4APDE4BPDE4CPDE4DHTR2B | |
| SCHEMBL9977546 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL23509448 | 0.86 | PDE4B (0.75) | PDE4APDE4BPDE4CPDE4DHTR2B | |
| SCHEMBL7440313 | 0.85 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7432884 | 0.85 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DTNF | |
| Cdc-801 SCHEMBL185853 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637167 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL9977581 | 0.84 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083153-A1 | OLIGOMER-CONTAINING APREMILAST MOIETY COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2012-06-21 | — | — | WO | disclosed |