Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 19/20 | 1.00 |
| ▸ | PDE4A | P27815 | 13/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 13/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195086 | 1.00 | PDE4B (1.00) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537489 | 0.92 | PDE4B (0.85) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL540337 | 0.91 | PDE4B (0.82) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL26546185 | 0.91 | PDE4B (0.82) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| Hydrochloric Acid SCHEMBL537170 | 0.90 | PDE4B (0.81) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL9977589 | 0.90 | PDE4B (1.00) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL1194004 | 0.90 | PDE4B (1.00) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL4435165 | 0.89 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537071 | 0.89 | PDE4B (1.00) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537805 | 0.89 | PDE4B (1.00) | PDE4BPDE4CPDE4APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083153-A1 | OLIGOMER-CONTAINING APREMILAST MOIETY COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2012-06-21 | — | — | WO | disclosed |