Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.50 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | FLT3 | P36888 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199008 | 1.00 | GSK3A (0.50) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9977763 | 1.00 | GSK3A (0.50) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL16199386 | 1.00 | GSK3A (0.50) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL16199030 | 0.92 | GSK3A (0.51) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL16199007 | 0.92 | GSK3A (0.51) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL16199109 | 0.92 | GSK3A (0.51) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9941189 | 0.92 | GSK3A (0.59) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9977761 | 0.92 | GSK3A (0.59) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL9977762 | 0.92 | GSK3A (0.59) | GSK3AGSK3BFLT3JAK2SRC | |
| SCHEMBL15400610 | 0.92 | GSK3A (0.59) | GSK3AGSK3BFLT3JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871774-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-28 | — | — | US | disclosed |
| WO-2012083117-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |