Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000594 | 0.82 | POLB (0.71) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL6007306 | 0.82 | MAPT (0.65) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL1079130 | 0.82 | MAPT (0.65) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL1078960 | 0.81 | MAPT (0.88) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL1000642 | 0.81 | POLB (0.59) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL1000874 | 0.80 | MAPT (0.58) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL999129 | 0.80 | MAPT (0.57) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL997703 | 0.78 | MAPT (0.62) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL1001595 | 0.77 | MAPT (0.76) | MAPTNPSR1POLBMEN1KMT2A | |
| SCHEMBL999097 | 0.77 | MAPT (0.75) | MAPTNPSR1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |