Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GBA1 | P04062 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | LATS1 | O95835 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9979110 | 0.80 | CYP1A2 (0.52) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL9979369 | 0.79 | LATS1 (0.51) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL12039897 | 0.79 | CYP1A2 (0.55) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL9979331 | 0.78 | LATS1 (0.50) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL1062736 | 0.76 | PDE5A (0.89) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7437119 | 0.76 | PDE5A (0.74) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL9979245 | 0.76 | IRAK1 (0.45) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL7285873 | 0.76 | PDE5A (0.78) | PDE5APTGS1TBXAS1PTGS2MEN1 | |
| SCHEMBL9979356 | 0.75 | NPC1 (0.43) | MEN1KMT2AALDH1A1TSHRGBA1 | |
| SCHEMBL4863906 | 0.75 | PDE5A (0.75) | PDE5APTGS1TBXAS1PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | COX CHRISTOPHER D (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319409-A1 | 7-AZA-QUINAZOLINE PDE10 INHIBITORS | PDE5A, PDE12, PDE7B | PDE5A 1/4885PTGS1 705/4885TBXAS1 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.