Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941216 | 0.77 | TBXA2R (0.37) | — | |
| SCHEMBL9940520 | 0.73 | CYP3A4 (0.45) | — | |
| SCHEMBL15685258 | 0.71 | — | — | |
| SCHEMBL23100599 | 0.71 | — | — | |
| SCHEMBL23100656 | 0.71 | — | — | |
| SCHEMBL17083961 | 0.71 | — | — | |
| SCHEMBL16809273 | 0.70 | CYP3A4 (0.38) | — | |
| SCHEMBL23100884 | 0.70 | — | — | |
| SCHEMBL15685163 | 0.70 | — | — | |
| SCHEMBL9979854 | 0.69 | BACE1 (0.54) | BACE1NUDT1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080446-A1 | BENZIMIDAZOLE RESPIRATORY SYNCYTIAL VIRUS INHIBITORS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |