SCHEMBL9982142

SCHEMBL9982142

COc1cc(-c2ccccn2)ccc1-n1ccc(=O)c(-c2cc(C)nn2-c2cccc(C(F)(F)F)c2)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.47
CYP3A4 P08684 3/20 0.47
CYP2C19 P33261 3/20 0.47
CYP2C9 P11712 3/20 0.47
ALDH1A1 P00352 1/20 0.47
PSEN1 P49768 8/20 0.44
PSEN2 P49810 8/20 0.44
APH1B Q8WW43 8/20 0.44
NCSTN Q92542 8/20 0.44
APH1A Q96BI3 8/20 0.44
PSENEN Q9NZ42 8/20 0.44
MEN1 O00255 1/20 0.43
MAPT P10636 1/20 0.43
KMT2A Q03164 1/20 0.43
GAA P10253 1/20 0.38
KCNH2 Q12809 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
PDE10A Q9Y233 1/20 0.37
SCN9A Q15858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12046082 0.91 CYP1A2 (0.51) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9981113 0.90 PDE10A (0.49) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9981828 0.90 PDE10A (0.48) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9981028 0.90 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9981074 0.90 HTT (0.39) ALDH1A1MEN1MAPTKMT2AGAA
SCHEMBL9982157 0.89 F10 (0.43) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9980890 0.83 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9981089 0.82 PSEN1 (0.42) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL12046097 0.82 PDE10A (0.51) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1
SCHEMBL9980989 0.82 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C19CYP2C9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9226921-B2 Fused heterocyclic compounds as phosphodiesterases (PDES) inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-01-05 US disclosed
US-8940758-B2 Fused heterocyclic compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-01-27 US disclosed
US-8940758-B2 Fused heterocyclic compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-01-27 US disclosed
US-8846713-B2 Fused heterocyclic compounds as phosphodiesterases (PDEs) inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-30 US disclosed
US-8846713-B2 Fused heterocyclic compounds as phosphodiesterases (PDEs) inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-30 US disclosed
US-20140228320-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-08-14 US disclosed
US-20140228320-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-08-14 US disclosed
US-20130303553-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2013-11-14 US disclosed
US-20130303553-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2013-11-14 US disclosed
US-8563575-B2 Fused heterocyclic compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-10-22 US disclosed
US-8563575-B2 Fused heterocyclic compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-10-22 US disclosed
US-20130172328-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS CROSSWING INC. (CA) 2013-07-04 US disclosed
US-20130172328-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS CROSSWING INC. (CA) 2013-07-04 US disclosed
US-20110319394-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-29 US disclosed
US-20110319394-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130172328-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS PDE3A, PDE5A, PDE2A CYP1A2 181/4885CYP3A4 757/4885CYP2C19 337/4885
US-20110319394-A1 FUSED HETEROCYCLIC COMPOUNDS PDE5A, PDE2A, PDE3A CYP1A2 155/4885CYP3A4 463/4885CYP2C19 306/4885
US-20130303553-A1 FUSED HETEROCYCLIC COMPOUNDS PDE5A, PDE2A, PDE3A CYP1A2 155/4885CYP3A4 463/4885CYP2C19 306/4885
US-20140228320-A1 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS PDE3A, PDE5A, PDE2A CYP1A2 181/4885CYP3A4 757/4885CYP2C19 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.