Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.48 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10304939 | 0.88 | PDE2A (0.47) | ABL1HSP90AA1HSP90AB1TRAP1CTSA | |
| SCHEMBL10305012 | 0.84 | HSP90AA1 (0.46) | ABL1HSP90AA1HSP90AB1BTKAR | |
| SCHEMBL10304970 | 0.84 | HSP90AA1 (0.50) | ABL1HSP90AA1HSP90AB1TRAP1CTSA | |
| SCHEMBL13745269 | 0.83 | HSP90AA1 (0.50) | ABL1HSP90AA1HSP90AB1TRAP1BTK | |
| SCHEMBL10304967 | 0.83 | HSP90AA1 (0.47) | ABL1HSP90AA1HSP90AB1BTK | |
| SCHEMBL10305102 | 0.80 | HSP90AA1 (0.48) | ABL1HSP90AA1HSP90AB1PDE2APDE10A | |
| SCHEMBL19153108 | 0.80 | HSP90AA1 (0.47) | ABL1HSP90AA1HSP90AB1TRAP1BTK | |
| SCHEMBL10305014 | 0.79 | FFAR1 (0.39) | HSP90AA1HSP90AB1TRAP1BTK | |
| SCHEMBL10304963 | 0.78 | PDE2A (0.48) | HSP90AA1HSP90AB1BTKPDE2APDE6D | |
| SCHEMBL10305037 | 0.78 | BTK (0.42) | HSP90AA1HSP90AB1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252595-B1 | OXIM DERIVATIVES AS HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2014-03-26 | — | — | EP | disclosed |
| US-20120264770-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-10-18 | — | — | US | disclosed |
| US-20120172321-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-05 | — | — | US | disclosed |
| US-8211885-B2 | Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals | SANOFI-AVENTIS (FR) | 2012-07-03 | — | — | US | disclosed |
| US-20090305998-A1 | HSP90 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090305998-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | ABL1 177/4885HSP90AA1 2/4885HSP90AB1 1/4885 |
| US-20120264770-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | ABL1 177/4885HSP90AA1 2/4885HSP90AB1 1/4885 |
| US-20120172321-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | ABL1 177/4885HSP90AA1 2/4885HSP90AB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.