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SCHEMBL9983128

SCHEMBL9983128

[2H]OC(=O)C([2H])C([2H])([2H])c1ccc(OCc2cc(F)cc3c2OC(C)(C)C3)c(F)c1CCC

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 1/20 0.39
▸ KDM5A P29375 1/20 0.32
▸ KDM4C Q9H3R0 1/20 0.32
▸ FFAR4 Q5NUL3 4/20 0.32
▸ DHFR P00374 1/20 0.31
▸ GYS1 P13807 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2433679 0.90 KMT2A (0.40) KMT2AKDM5AKDM4CFFAR4DHFR
SCHEMBL2433283 0.85 KMT2A (0.41) KMT2AKDM5AKDM4CFFAR4
SCHEMBL2435899 0.83 KMT2A (0.41) KMT2AKDM5AKDM4CFFAR4GYS1
SCHEMBL2432995 0.80 FFAR4 (0.39) KMT2AFFAR4
SCHEMBL2428511 0.80 FFAR4 (0.41) KMT2AKDM5AKDM4CFFAR4
SCHEMBL2434673 0.80 FFAR4 (0.40) KMT2AKDM5AKDM4CFFAR4
SCHEMBL2438236 0.79 KMT2A (0.42) KMT2AKDM5AKDM4CFFAR4
SCHEMBL2434960 0.78 FFAR4 (0.49) KMT2AFFAR4
SCHEMBL9983204 0.77 KMT2A (0.44) KMT2AKDM5AKDM4CFFAR4GYS1
SCHEMBL2433634 0.76 KMT2A (0.40) KMT2AKDM5AKDM4CFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582674-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF Metabolex Inc. (US) 2013-04-24 — — EP disclosed
WO-2011159297-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2011-12-22 — — WO disclosed